CLINICAL AND IMMUNOLOGICAL FEATURES OF THE CONTEMPORARY FLU IN CONDITION OF EPIDEMIC RISE

Svistunova Natalya Vladimirovna, Doctor, Penza Region Center of Specialized Medical Care, snv.10@mail.ru
Baranova Irina Petrovna, Doctor of medical sciences, professor, head of sub-departament of infectious diseases, Penza Institut of advanced medical studies, snv.10@mail.ru

616.921.5:612.017.1

The article introduces analysis results of clinical features of an influenza virus infection during the pandemia of 2009–2010 and seasonal increase of the incidences of a disease in 2010–2011 of 166 hospital patients at the age from 8 months to 61 years. Characteristics of a clinical presentation and difference between an influenza A(Н1N1) and an influenza B are educed. Changes of concentration of a pro-inflammatory cytokine the TNF-α and levels of output of interferons α аnd γ in blood serum are examined on the ground of 39 patients with moderately severe influenza virus infection in the beginning of disease and in early recovery. Prognostic indica-tors of severe acute disease are defined on the basis of characteristics of concentra-tion fluctuations of cytokines in patients with influenza virus infection.

influenza virus infection, clinical presentation, complications, interferon status, factor of a tumor necrosis-α.